PENICILLIN G, SODIUM SALT

PHYSICAL DESCRIPTION: White to slightly yellow crystalline powder with a faint odor. pH (10% solution) 5.5-7.5. (NTP, 1992)

none

Water soluble.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: This chemical is a strong allergen and the reaction may be severe in susceptible people. Symptoms of exposure to this compound include hypersensitivity, skin rashes (ranging from maculopapular eruptions to exfoliative dermatitis), urticaria, chills, fever, edema, arthralgia, prostration, severe and occasionally fatal anaphylaxis, hemolytic anemia, leukopenia, thrombocytopenia, neuropathy and nephropathy. Subsequent exposures can lead to more serious reactions of the serum sickness type. Encephalopathy may result in those with renal failure. Other symptoms include pallor, cyanosis, wheezing, collapse, frothy sputum, pulmonary edema and death. It may also cause eosinophilia, joint pain, angioneurotic edema, erythema multiforme, prolongation of bleeding time, defective platelet function, glossitis, angular and aphthous stomatitis, darkening of the tongue, convulsions and other signs of toxicity to the central nervous system (at high doses), acute interstitial nephritis, disturbances of blood electrolytes, transient diarrhea, nausea, heartburn, pruritis ani, abdominal pain, pancytopenia, hemorrhagic diathesis, hypokalemia, metabolic alkalosis, systemic lupus erythematosus, pneumonitis, dyspnea, oliguria, confusion, myoclonic jerks, seizures, coma, bronchopneumonia, sciatic neuritis, epidermal necrolysis and Stevens-Johnson syndrome Nephrotoxicity has occurred in some people with diminished renal function when given large doses.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits highly toxic fumes of NOx and SOx. (NTP, 1992)

PENICILLIN G, SODIUM SALT is hygroscopic. This compound is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. It is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. It may also be incompatible with naphthalene oils and vitamin B. (NTP, 1992)

• Salts, Acidic Inorganic/Organic
• Amides and Imides, Organic
• Sulfides, Organic

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this material under ambient temperatures and protect it from moisture. Keep it away from oxidizing agents and acids. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• 2-CARBOXYLIC ACID, MONOSODIUM SALT
• 3,3-DIMETHYL-7-OXO-6-(2-PHENYL=ACETAMIDO)-4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-
• 4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, 3,3-DIMETHYL-7-OXO-6-(2-PHENYLACETAMIDO)-, MONOSODIUM SALT
• 4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, 3,3-DIMETHYL-7-OXO-6-[(PHENYLACETYL)AMINO]-[2S-(2ALPHA,5ALPHA,6.BETA]).-, MONOSODIUM SALT
• AMERICAN PENICILLIN
• BENZYLPENICILLIN SODIUM
• BENZYLPENICILLIN SODIUM SALT
• BENZYLPENICILLINIC ACID SODIUM SALT
• CRYSTAPEN
• MONOSODIUM BENZYLPENICILLIN
• MYCOFARM
• NALPEN G
• NOVOCILLIN
• PEN-A-BRASIVE
• PENICILLIN
• PENICILLIN G SODIUM
• PENICILLIN G SODIUM SALT
• PENICILLIN-G, MONOSODIUM SALT
• PENICILLIN-G, SODIUM
• PENILARYN
• SODIUM 6-(PHENYLACETAMIDO)PENICILLANATE
• SODIUM BENZYL PENICILLIN
• SODIUM BENZYLPENICILLIN
• SODIUM BENZYLPENICILLIN G
• SODIUM BENZYLPENICILLINATE
• SODIUM PENICILLIN
• SODIUM PENICILLIN G
• SODIUM PENICILLIN II
• VETICILLIN