TETRACYCLINE HYDROCHLORIDE

PHYSICAL DESCRIPTION: Crystals or fine bright yellow powder. pH of 2% aqueous solution: 2.1 - 2.3. (NTP, 1992)

none

Water soluble.

Flash point data concerning this compound are not available, however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound may include the following gastrointestinal effects: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, inflammatory lesions in the anogenital region, and hepatic toxicity. Skin effects include maculopapular and erythematous rashes, exfoliative dermatitis and photosensitivity. Renal effects include a rise in BUN and hypersensitivity reactions include urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, pericarditis and exacerbation of systemic lupus erythematosus, and bulging fontanels have been reported in young infants. Blood effects include hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia. Symptoms of exposure to this type of compound may include epigastric burning and distress, and abdominal discomfort.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of carbon monoxide, carbon dioxide, NOx, and hydrogen chloride gas. (NTP, 1992)

TETRACYCLINE HYDROCHLORIDE is acidic. Reacts with strong oxidizing agents (NTP, 1992).

• Salts, Acidic Inorganic/Organic
• Amides and Imides, Organic

Fires involving this material can be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• 2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-, MONOHYDROCHLORIDE
• 2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-, MONOHYDROCHLORIDE, [4S-(4ALPHA,4AALPHA,5AALPHA,6BETA,12A.ALPHA]).-
• 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,12A-PENTA-HYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE, MONO-HYRDOCHLORIDE
• ACHRO
• ACHROMYCIN HYDROCHLORIDE
• ACHROMYCIN V
• ALA TET
• AMBRACYN
• ARTROMYCIN
• BRISTACICLINA
• BRISTACYCLINE
• CANCYCLINE-250
• CEFRACYCLINE TABLETS
• CYCLOPAR
• DIACYCLINE
• DUMOCYCLIN
• FERMENTMYCIN
• HOSTACYCLIN
• HOSTACYCLINE
• MEDAMYCIN
• MEPHACYCLIN
• NCI-C55561
• NEOCYCLINE B
• PALTET
• PANMYCIN
• PANMYCIN HYDROCHLORIDE
• PARTREX
• POLYCYCLINE HYDROCHLORIDE
• POLYOTIC OINTMENT
• QUADRACYCLINE
• SANCLOMYCINE
• STECLIN
• STECLIN HYDROCHLORIDE
• SUBAMYCIN
• SUPRAMYCIN
• TET-CY
• TETRABID
• TETRACAPS
• TETRACYCLINE CHLORIDE
• TETRACYCLINE CHLOROHYDRATE
• TETRACYN
• U-5965
• UNIMYCIN