Chemical data sheet for:
BETA-PROPIOLACTONE
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| Section 1 - Chemical Identifiers | Section 4 - Physical Properties |
| Section 2 - Hazards | Section 5 - Regulatory Information |
| Section 3 - Response Recommendations | Section 6 - Alternate Chemical Names |
Section 1 - Chemical Identifiers
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| CAS Number | UN/NA Number | STCC Number | CHRIS Code |
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none |
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| NFPA 704: |
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DOT Hazard Label: |
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General Description
A colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments. (EPA, 1998)
Section 2 - Hazards
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Reactivity Alerts
none
Air & Water Reactions
Slow reaction with water to form beta- hydroxypropionic acid.
Fire Hazard
Containers may explode. When heated to decomposition, it emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures. (EPA, 1998)
Health Hazard
The toxicity potential of this material via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen. (EPA, 1998)
Reactivity Profile
BETA-PROPIOLACTONE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This chemical may be incompatible with alkalis. (NOAA REACTIVITY, 2007)
Belongs to reactive group(s)
- Esters
Section 3 - Response Recommendations
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Fire Fighting
Wear air mask, goggles or face shield, rubber gloves, and protective clothing to prevent all skin contact. Cool exposed containers with water.
Extinguish with alcohol foam, water, dry chemical, foam, or carbon dioxide. (EPA, 1998)
Extinguish with alcohol foam, water, dry chemical, foam, or carbon dioxide. (EPA, 1998)
Non-Fire Response
Avoid contact with liquid. Keep people away. Stop discharge. Avoid inhalation. (EPA, 1998)
Protective Clothing
Skin: Wear appropriate personal protective clothing to prevent skin contact.
Eyes: Wear appropriate eye protection to prevent eye contact.
Wash skin: The worker should immediately wash the skin when it becomes contaminated. The worker should wash daily at the end of each work shift.
Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise.
Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2003)
Eyes: Wear appropriate eye protection to prevent eye contact.
Wash skin: The worker should immediately wash the skin when it becomes contaminated. The worker should wash daily at the end of each work shift.
Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise.
Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2003)
First Aid
Warning: Propiolactone, beta- is an animal carcinogen. Toxicity potential via inhalation and ingestion is high. May cause death or permanent injury after very short exposures to small quantities. Propiolactone, Beta- also is an irritant; effects may be delayed.
Signs and Symptoms of Propiolactone, Beta- Exposure: Acute exposure to propiolactone, beta- may include irritation to skin, eyes, mouth, esophagus, GI tract, and respiratory tract. Liver and kidney injury, dyspnea (difficult or labored breathing), and convulsions may also be noted.
Emergency Life-Support Procedures: Acute exposure to propiolactone, beta- may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to propiolactone, beta-.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
4. Rush to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to propiolactone, beta-.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Rush to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. DO NOT induce vomiting.
4. Following ingestion, immediately dilute with 4 to 8 ounces (120 to 140 mL) of milk or water not to exceed 15 mL/kg in a child).
5. Rush to a health care facility. (EPA, 1998)
Signs and Symptoms of Propiolactone, Beta- Exposure: Acute exposure to propiolactone, beta- may include irritation to skin, eyes, mouth, esophagus, GI tract, and respiratory tract. Liver and kidney injury, dyspnea (difficult or labored breathing), and convulsions may also be noted.
Emergency Life-Support Procedures: Acute exposure to propiolactone, beta- may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to propiolactone, beta-.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
4. Rush to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to propiolactone, beta-.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Rush to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. DO NOT induce vomiting.
4. Following ingestion, immediately dilute with 4 to 8 ounces (120 to 140 mL) of milk or water not to exceed 15 mL/kg in a child).
5. Rush to a health care facility. (EPA, 1998)
Section 4 - Physical Properties
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| Molecular Formula: |
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Flash Point: 158.0 ° F (EPA, 1998)
Lower Explosive Limit: 2.9 % (EPA, 1998)
Upper Explosive Limit: data unavailable
Auto Ignition Temperature: data unavailable
Melting Point: -27.0 ° F (EPA, 1998)
Vapor Pressure: 3.4 mm Hg at 77.0 ° F (EPA, 1998)
Vapor Density: 2.5 (NTP, 1992)
Specific Gravity: 1.146 at 68.0 ° F (EPA, 1998)
Boiling Point: 324.0 ° F at 760 mm Hg decomposes (EPA, 1998)
Molecular Weight: 72.06 (EPA, 1998)
Water Solubility: 10-50 mg/mL at 66° F (NTP, 1992)
AEGL: data unavailable
ERPG: use TEEL data
| TEEL-1 | TEEL-2 | TEEL-3 |
| 0.509 ppm | 5.0 ppm | 15.0 ppm |
| (TEEL, 2003) |
IDLH: data unavailable
Section 5 - Regulatory Information
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Regulatory Names
- BETA-PROPIOLACTONE
CAA RMP: Not a regulated chemical.
CERCLA: Regulated chemical with a Reportable Quantity of 10 pounds.
EPCRA 302 EHS: Regulated chemical with a Reportable Quantity of 10 pounds and a Threshold Planning Quantity of 500 pounds.
TRI (EPCRA 313): Regulated chemical.
RCRA chemical code: none
Section 6 - Alternate Chemical Names
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- 1,3-PROPIOLACTONE
- 2-OXETANONE
- 3-HYDROXY-BETA-LACTONE
- 3-HYDROXY-PROPIONIC ACID
- 3-HYDROXYPROPIONIC ACID BETA-LACTONE
- 3-HYDROXYPROPIONIC ACID, BETA-LACTONE
- 3-HYDROXYPROPIONIC ACID LACTONE
- 3-PROPANOLIDE
- 3-PROPIOLACETONE
- 3-PROPIOLACTONE
- BETA-LACTONE
- BETA-PROPIONOLACTONE
- BETA-PROPROLACTONE
- BETAPRONE
- BETRAPRONE
- BPL
- HYDRACRYLIC ACID, BETA LACTONE
- HYDRACRYLIC ACID BETA-LACTONE
- HYDRACRYLIC ACID, BETA-LACTONE
- HYDROACRYLIC ACID, BETA-LACTONE
- NSC-21626
- OXETAN-2-ONE
- PROPANILIDE
- PROPANOIC ACID, 3-HYDROXY-, BETA-LACTONE
- PROPANOIC ACID, 3-HYDROXY-,BETA-LACTONE
- PROPANOLIDE
- PROPIOLACTONE
- PROPIOLACTONE, BETA-
- PROPIONIC ACID, 3-HYDROXY-, BETA-LACTONE
- PROPIONIC ACID 3-HYDROXY-BETA-LACTONE
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